2018-09-06 18:42:112025-03-12 21:40:45
locus
BSU03890
BSU_03890
geneLength
1437
1440
outlinks
bsu
BSU03890
BSU_03890
The protein
Protein family
[SW|MocR/ GabR family] [Pubmed|22020104]
[SW|MocR/ GabR family] [Pubmed|22020104]
[SW|class-I pyridoxal-phosphate-dependent aminotransferase family] (according to UniProt)
The protein
[SW|Domains]
N-terminal DNA-binding helix-turn-helix motif (corresponding to domains of the [SW|GntR family]) [Pubmed|24127574]
C-terminal domain is homologous to PLP-binding large domain of aminotransferases [Pubmed|24127574]
N-terminal DNA-binding helix-turn-helix motif (corresponding to domains of the [SW|GntR family]) [Pubmed|24127574]
C-terminal domain is homologous to PLP-binding large domain of aminotransferases [Pubmed|24127574]
[SW|HTH gntR-type domain] (aa 14-82) (according to UniProt)
The protein
[SW|Cofactors]
gamma-aminobutyric acid, PLP [Pubmed|24127574]
gamma-aminobutyric acid, PLP [Pubmed|31848410,24127574]
The protein
Effectors of protein activity
activation of ''[[gene|gabT]]-[[gene|gabD]]'' expression is triggered by gamma-amino butyrate and pyridoxalphosphate [Pubmed|15223311]
activation of ''[[gene|gabT]]-[[gene|gabD]]'' expression is triggered by gamma-amino butyrate and pyridoxalphosphate [Pubmed|15223311]
in the absence of GABA, GabR represses [[gene|gabT]]-[[gene|gabD]] expression, whereas binding of GABA to GabR results in a conformational change resulting in activation of transcription [pubmed|32147931]
Labs working on this gene/protein
[SW|Linc Sonenshein], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]
References
labs
[SW|Linc Sonenshein], Tufts University, Boston, MA, USA [http://www.tufts.edu/sackler/microbiology/faculty/sonenshein/index.html Homepage]